BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer.
@article{Cheng2014BMP8BMT,
title={BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer.},
author={Zhuo-xin Cheng and Wu Cui and Ye Ding and Tao Liu and Weixin Liu and Youyou Qin and Weibin Xia and Jian Xu and Ying-Hai Zhang and Xiaoming Zou},
journal={Oncology reports},
year={2014},
volume={32 5},
pages={
1861-6
}
}Pancreatic cancer has become one of the most common types of cancer. It is believed that inhibiting the apoptosis of tumor cells as well as overgrowth of tumor cells accelerate the progression and development of cancer. However, the detailed mechanisms of pancreatic cancer progression remain to be fully elucidated. Although bone morphogenetic protein (BMP) families are crucial mediators in some types of cancer, whether BMP8B is involved in regulating the growth and apoptosis of pancreatic…
Topics from this paper
10 Citations
BMP8B Is a Tumor Suppressor Gene Regulated by Histone Acetylation in Gastric Cancer
- BiologyJournal of cellular biochemistry
- 2017
It is demonstrated that BMP8B seems to be a tumor suppressor gene regulated by H4K16 acetylation in poorly differentiated GC, which may be a potential target for TSA‐based therapies in this GC sample subset.
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis
- Biology, MedicineNature metabolism
- 2020
Hepatic bone morphogenetic protein 8b expression is shown to be induced in NASH to drive wound healing responses and NASH progression by promoting inflammatory pathways in hepatic stellate cells and, more broadly, in the liver parenchyma.
Bone Morphogenetic Protein-8B Expression is Induced in Steatotic Hepatocytes and Promotes Hepatic Steatosis and Inflammation In Vitro
- Biology, MedicineCells
- 2019
Analysis of the expression of key factors of hepatocellular lipid transport and metabolisms indicated that BMP8B effects on fatty acid uptake as well as de novo lipogenesis contributed to hepato cellular accumulation of fatty acids leading to increased storage in the form of triglycerides and enhanced combustion by beta oxidation.
Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn’s Disease
- Biology, MedicineGenes
- 2021
Differences in expression profiles between UC and CD for INSL5, LEFTY1 and BMP8B are found and these three promising candidate genes need to be further explored at different levels, such as DNA methylation and protein expression, to provide more evidence on their potential diagnostic role in CD and UC.
Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness
- Biology
- 2020
It is shown that methylmalonic acid (MMA), a by-product of propionate metabolism, is significantly up-regulated in the serum of older people, and functions as a mediator of tumor progression.
Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity
- BiologyNucleic acids research
- 2015
Findings provide evidence that post-transcriptional studies of BRCA will benefit from transcending the one-locus-one-miRNA paradigm and taking into account all isoforms from each miRNA locus as well as the patient's race.
Marigold Supercritical Extract as Potential Co-adjuvant in Pancreatic Cancer: The Energetic Catastrophe Induced via BMP8B Ends Up With Autophagy-Induced Cell Death
- BiologyFrontiers in Bioengineering and Biotechnology
- 2019
The antitumoral properties and mechanism of action of a supercritical CO2 extract from Calendula officinalis, commonly known as marigold (marigold SFE) in the context of pancreatic cancer is investigated.
Identification of laryngeal cancer prognostic biomarkers using an inflammatory gene-related, competitive endogenous RNA network
- BiologyOncotarget
- 2017
This work constructed an LC-specific inflammatory gene-related ceRNA network (IceNet), and identified a potential prognostic module within IceNet that contains 18 mRNAs and a long non-coding RNA (lncRNA), and effectively stratified patients into high- and low-risk subgroups with different survival outcomes, independent of patient age and tumor grade.
Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene
- Medicine, BiologyBMC Medical Genetics
- 2018
A potentially deleterious somatic heterozygous mutation in bone morphogenetic protein 8B (BMP8B) gene (c.1139A > G, Tyr380Cys) that was identified in the pulmonary metastasis and was absent from blood and uterine leiomyoma, and may play a facilitating role in the metastasizing of BML.
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
- Biology, MedicineJournal of Lipid Research
- 2019
The diverse signaling mediators and mechanisms adipose tissue utilizes to relay information to other organs are reviewed and recently identified adipokines (proteins, lipids, and metabolites) are discussed and the contributions of noncoding RNAs and EVs to the ever-increasing complexities of adipose tissues inter-organ communication are outlined.
References
SHOWING 1-10 OF 25 REFERENCES
BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression
- Biology, MedicineMolecular Biology Reports
- 2013
Observations indicate that BMP9 is an important mediator of breast cancer bone metastasis and a potential therapeutic target for treating this deadly disease.
BMP7 influences proliferation, migration, and invasion of breast cancer cells.
- Biology, MedicineCancer letters
- 2009
Identification of bone morphogenetic proteins and their receptors in human breast cancer cell lines: importance of BMP2.
- Biology, MedicineCytokine
- 1999
The number of tissues that contain bone morphogenetic proteins (BMPs) is expanded and the effect of this signalling pathway of the growth state of these tissues is demonstrated.
Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis?
- BiologyEndocrine-related cancer
- 2010
This review focuses on the current knowledge of BMP expression, functional roles and involvement in bone metastasis in breast cancer.
Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5
- Biology, MedicineOncogene
- 2006
It is shown that BMP-2 induces Id-1 expression in lung cancer cell lines through its activation of Smad-1/5, which is dependent on cell culture conditions, and its activity varies depending on the local environment.
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
- Biology, MedicineNature
- 2006
Findings show that the BMP–BMPR signalling system—which controls the activity of normal brain stem cells—may also act as a key inhibitory regulator of tumour-initiating, stem-like cells from GBMs and identify BMP4 as a novel, non-cytotoxic therapeutic effector, which may be used to prevent growth and recurrence of GBMs in humans.
Gene expression of bone morphogenic protein 8B in the primary site, peripheral blood and bone marrow of patients with gastric cancer
- Medicine, BiologyOncology letters
- 2013
Bone morphogenetic protein 8B, a previously unknown secreted factor in cancer progression, has the potential to be used as a prognostic biomarker and may provide insight into a new mechanism that underlies the dissemination of gastric cancer cells.
Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice.
- Biology, MedicineCancer research
- 2007
It is hypothesized that the regulation of epithelial cell fate may be less well defined in these junctional zones than in the adjacent epithelium and found that the mucosa at the squamocolumnar junction in mice shows a lack of differentiated fundic gland cell types and thatfoveolar cells at the gastrointestinal junctional zone lack expression of the foveolar cell marker Muc5ac.
Developments in Burkitt’s lymphoma: novel cooperations in oncogenic MYC signaling
- BiologyCancer management and research
- 2014
There is synergistic cooperation between c-MYC and PI3-kinase during BL development and this model may, therefore, prove useful in further studies to identify functionally relevant mutational events necessary for BL pathogenesis.
Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo.
- Biology, ChemistryCancer letters
- 2010