• Corpus ID: 90265335

BMP4 signaling pathways progenitor cells by combined modulation of the MEK/ERK and + CD34 Efficient differentiation of human pluripotent stem cells into functional

@inproceedings{Kim2011BMP4SP,
  title={BMP4 signaling pathways progenitor cells by combined modulation of the MEK/ERK and + CD34 Efficient differentiation of human pluripotent stem cells into functional},
  author={Min-Jeong Kim and Chulhee Choi and Yee Sook Cho and Hyung-Min Chung and Gou Young Koh and Yong-Mahn Sang-Wook and Juneyoung Koh and Jong Wook Jeon and Yun-Hee Cho and Mi-Jin Jang and Yujung Kang},
  year={2011}
}
http://bloodjournal.hematologylibrary.org/cgi/content/full/116/25/5762 Updated information and services can be found at: (203 articles) Vascular Biology • (2759 articles) Hematopoiesis and Stem Cells • collections: Blood Articles on similar topics may be found in the following http://bloodjournal.hematologylibrary.org/misc/rights.dtl#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/misc… 
kiko-tech.co.jp

Figures from this paper

References

SHOWING 1-10 OF 49 REFERENCES
TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.
TLDR
It is shown that in ex vivo mouse blastocyst cultures, SMAD2/3 signaling is also required to maintain the inner cell mass (from which stem cells are derived), demonstrating an interconnection between TGFbeta and WNT signaling in these contexts.
TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
TLDR
It is shown that in ex vivo mouse blastocyst cultures, SMAD2/3 signaling is also required to maintain the inner cell mass (from which stem cells are derived), demonstrating an interconnection between TGFβ and WNT signaling in these contexts.
The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.
TLDR
Bioinformatic analysis of expression changes observed when these cells were induced to differentiate as embryoid bodies suggested that quite a few of the downregulated genes were components of signal transduction networks and implicated components of the PI3K/AKT kinase, MAPK/ERK and NFkappabeta pathways and confirmed that these components are decreased upon differentiation.
A Boost of BMP4 Accelerates the Commitment of Human Embryonic Stem Cells to the Endothelial Lineage
TLDR
It is shown that bone morphogenetic protein 4 (BMP4), an inducer of mesoderm, accelerates the peak expression of CD133/kinase insert domain‐containing receptor (KDR) and CD144/KDR and, initially, the BMP4‐boosted day 7, CD144+KDR+CD31− population represents immature endothelial cells that differentiate into mature endothelium cells in culture.
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells.
TLDR
Several complementary methods are used to demonstrate the importance of canonical Wnt signaling to mediate development of early hematoendothelial progenitors during human development.
Dose-Dependent Contribution of CD34-Positive Cell Transplantation to Concurrent Vasculogenesis and Cardiomyogenesis for Functional Regenerative Recovery After Myocardial Infarction
TLDR
The hypothesis that vasculogenesis and cardiomyogenesis after myocardial infarction (MI) may be dose-dependently enhanced after CD34+ cell transplantation is proved.
Endothelial progenitor cells: diagnostic and therapeutic considerations.
TLDR
An update on multiple factors that affect EPC number is provided as well as highlighting the potential use of EPCs as a novel marker of vascular dysfunction and potential gene- and/or EPC-based approaches to a number of vascular disease states are explored.
Activin A Efficiently Specifies Definitive Endoderm from Human Embryonic Stem Cells Only When Phosphatidylinositol 3‐Kinase Signaling Is Suppressed
TLDR
It is shown that generation of hESC‐DE requires two conditions: signaling by Activin/Nodal family members and release from inhibitory signals generated by PI3K through insulin/IGF.
Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential.
TLDR
Data indicate that CD34+ cells generated through hES/OP9 coculture display several features of definitive hematopoietic stem cells.
...
1
2
3
4
5
...