BMP4 promotes chondrocyte proliferation and hypertrophy in the endochondral cranial base.

@article{Shum2003BMP4PC,
  title={BMP4 promotes chondrocyte proliferation and hypertrophy in the endochondral cranial base.},
  author={Lillian Shum and Xibin Wang and Alex A. Kane and Glen Nuckolls},
  journal={The International journal of developmental biology},
  year={2003},
  volume={47 6},
  pages={423-31}
}
Defects in the growth and development of the endochondral bones that comprise the cranial base contribute to several craniofacial dysmorphic syndromes. Since Bone Morphogenetic Protein (BMP) signaling regulates chondrocyte differentiation and endochondral ossification in developing long bones, we have tested the hypothesis that BMP signaling also participates in regulating development of the cranial base. During in vivo developmental progression of the cranial base in mice, a burst of skeletal… CONTINUE READING