BMP4 is essential for lens induction in the mouse embryo.

  title={BMP4 is essential for lens induction in the mouse embryo.},
  author={Yasuhide Furuta and Brigid L. M. Hogan},
  journal={Genes & development},
  volume={12 23},
Vertebrate lens development is a classical model system for studying embryonic tissue interactions. Little is known, however, about the molecules mediating such inductive events. Here, we show that Bmp4, which is expressed strongly in the optic vesicle and weakly in the surrounding mesenchyme and surface ectoderm, has crucial roles during lens induction. In Bmp4(tm1) homozygous null mutant embryos, lens induction is absent, but the process can be rescued by exogenous BMP4 protein applied into… CONTINUE READING
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