BMP4-expressing muscle-derived stem cells differentiate into osteogenic lineage and improve bone healing in immunocompetent mice.

@article{Wright2002BMP4expressingMS,
  title={BMP4-expressing muscle-derived stem cells differentiate into osteogenic lineage and improve bone healing in immunocompetent mice.},
  author={Vonda J. Wright and Hairong Peng and Arvydas Ūsas and Brett M Young and Brian Gearhart and James Cummins and Johnny Huard},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2002},
  volume={6 2},
  pages={169-78}
}
Recent advances in molecular biology have led the way for novel approaches to improve bone healing. The ideal growth factor, vector, and delivery systems for producing bone in an immune competent animal model, however, have yet to be identified. Using a retrovirus encoding BMP4 and recently isolated muscle-derived stem cells (MDSCs), we demonstrated the following: MDSCs undergo osteogenic differentiation in response to BMP4 in a dose-dependent manner; retrovirus encoding BMP4 can efficiently… CONTINUE READING
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