BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing

@article{Tsuji2006BMP2AA,
  title={BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing},
  author={Kunikazu Tsuji and Amitabha Bandyopadhyay and Brian D Harfe and Karen Cox and Sanjeev Kakar and Louis Gerstenfeld and Thomas Einhorn and Clifford J Tabin and Vicki Rosen},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={1424-1429}
}
Adult bones have a notable regenerative capacity. Over 40 years ago, an intrinsic activity capable of initiating this reparative response was found to reside within bone itself, and the term bone morphogenetic protein (BMP) was coined to describe the molecules responsible for it. A family of BMP proteins was subsequently identified, but no individual BMP has been shown to be the initiator of the endogenous bone repair response. Here we demonstrate that BMP2 is a necessary component of the… CONTINUE READING
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