BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity.

@article{Jun2010BMP2activatedEK,
  title={BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity.},
  author={Ji Hae Jun and Won-Joon Yoon and Sang-Beom Seo and K O Woo and Gwan-Shik Kim and Hyun-Mo Ryoo and Jeong-Hwa Baek},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 47},
  pages={36410-9}
}
Runx2 is a critical transcription factor for osteoblast differentiation. Regulation of Runx2 expression levels and transcriptional activity is important for bone morphogenetic protein (BMP)-induced osteoblast differentiation. Previous studies have shown that extracellular signal-regulated kinase (Erk) activation enhances the transcriptional activity of Runx2 and that BMP-induced Runx2 acetylation increases Runx2 stability and transcriptional activity. Because BMP signaling induces Erk… CONTINUE READING
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Erk Increases p300-mediated Runx2 Stabilization 36418 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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