BMP1 inhibitor UK-383,367 attenuates renal fibrosis and inflammation in CKD.

  title={BMP1 inhibitor UK-383,367 attenuates renal fibrosis and inflammation in CKD.},
  author={Mi Bai and Juan Lei and S. Wang and D. Ding and Xiaowen Yu and Y. Guo and Shuang Chen and Y. Du and Deyi Li and Yue Zhang and Songming Huang and Zhanjun Jia and A. Zhang},
  journal={American journal of physiology. Renal physiology},
  • Mi Bai, Juan Lei, +10 authors A. Zhang
  • Published 2019
  • Medicine
  • American journal of physiology. Renal physiology
  • Renal fibrosis is a key pathological phenomenon of chronic kidney disease (CKD), contributing to the progressive loss of renal function. UK383,367 is a procollagen C-proteinase inhibitor that has been selected as a candidate for dermal anti-scarring agent, while its role in renal fibrosis is unclear. In this study, UK383,367 was applied to a CKD mouse model of unilateral ureteral obstruction (UUO) and cell lines of renal tubular epithelial cells (mPTCs) and renal fibroblast cells (NRK-49F… CONTINUE READING
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