BMP1 inhibitor UK-383,367 attenuates renal fibrosis and inflammation in CKD.

  title={BMP1 inhibitor UK-383,367 attenuates renal fibrosis and inflammation in CKD.},
  author={Mi Bai and Juan Lei and Shuqin Wang and Dan Ding and Xiaowen Yu and Yan Guo and Shuang Chen and Yang Du and de Oliveira Li and Yue Zhang and Songming Huang and Zhanjun Jia and Aihua Zhang},
  journal={American journal of physiology. Renal physiology},
  • M. Bai, Juan Lei, A. Zhang
  • Published 1 December 2019
  • Medicine, Biology, Chemistry
  • American journal of physiology. Renal physiology
Renal fibrosis is a key pathological phenomenon of chronic kidney disease (CKD), contributing to the progressive loss of renal function. UK383,367 is a procollagen C-proteinase inhibitor that has been selected as a candidate for dermal anti-scarring agent, while its role in renal fibrosis is unclear. In this study, UK383,367 was applied to a CKD mouse model of unilateral ureteral obstruction (UUO) and cell lines of renal tubular epithelial cells (mPTCs) and renal fibroblast cells (NRK-49F… 
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