BMP type II receptor is required for gastrulation and early development of mouse embryos.

@article{Beppu2000BMPTI,
  title={BMP type II receptor is required for gastrulation and early development of mouse embryos.},
  author={Hideyuki Beppu and Masahiro Kawabata and Toshiaki Hamamoto and Anna M Chytil and Osamu Minowa and Takeshi Noda and Kohei Miyazono},
  journal={Developmental biology},
  year={2000},
  volume={221 1},
  pages={249-58}
}
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta superfamily, play a variety of roles during mouse development. BMP type II receptor (BMPR-II) is a type II serine/threonine kinase receptor, which transduces signals for BMPs through heteromeric complexes with type I receptors, including activin receptor-like kinase 2 (ALK2), ALK3/BMPR-IA, and ALK6/BMPR-IB. To elucidate the function of BMPR-II in mammalian development, we generated BMPR-II mutant mice by gene… CONTINUE READING
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