BMP signaling is required for cell cleavage in preimplantation-mouse embryos.

  title={BMP signaling is required for cell cleavage in preimplantation-mouse embryos.},
  author={Nabora Soledad Reyes de Mochel and Mui N Luong and Michael Chiang and Anna L. Javier and Elizabeth Luu and Fujimori Toshihiko and Grant R Macgregor and Olivier Cinquin and Ken W. Y. Cho},
  journal={Developmental biology},
  volume={397 1},
The mechanisms regulating cell division during development of the mouse pre-implantation embryo are poorly understood. We have investigated whether bone morphogenetic protein (BMP) signaling is involved in controlling cell cycle during mouse pre-implantation development. We mapped and quantitated the dynamic activities of BMP signaling through high-resolution immunofluorescence imaging combined with a 3D segmentation method. Immunostaining for phosphorylated Smad1/5/8 shows that BMP signaling… CONTINUE READING

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