BMP signaling during bone pattern determination in the developing limb.

@article{Kawakami1996BMPSD,
  title={BMP signaling during bone pattern determination in the developing limb.},
  author={Yasuhiko Kawakami and Tomo-o Ishikawa and Masakiyo Shimabara and Nobuya Tanda and Motomi Enomoto-Iwamoto and Masahiro Iwamoto and Takashi Kuwana and Ayako Ueki and Sumihare Noji and Tsutomu Nohno},
  journal={Development},
  year={1996},
  volume={122 11},
  pages={3557-66}
}
To examine the role of BMP signaling during limb pattern formation, we isolated chicken cDNAs encoding type I (BRK-1 and BRK-2) and type II (BRK-3) receptors for bone morphogenetic proteins. BRK-2 and BRK-3, which constitute dual-affinity signaling receptor complexes for BMPs, are co-expressed in condensing precartilaginous cells, while BRK-1 is weakly expressed in the limb mesenchyme. BRK-3 is also expressed in the apical ectodermal ridge and interdigital limb mesenchyme. BRK-2 is intensely… CONTINUE READING

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References

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A series of normal stages in the development of the chick embryo.

Journal of morphology • 1951
View 4 Excerpts
Highly Influenced

An additional limb can be induced from the flank of the chick embryo by FGF4.

Biochemical and biophysical research communications • 1995
View 2 Excerpts

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