BMP signaling during bone pattern determination in the developing limb.

  title={BMP signaling during bone pattern determination in the developing limb.},
  author={Yasuhiko Kawakami and Tomo-o Ishikawa and Masakiyo Shimabara and Nobuya Tanda and Motomi Enomoto-Iwamoto and Masahiro Iwamoto and Takashi Kuwana and Ayako Ueki and Sumihare Noji and Tsutomu Nohno},
  volume={122 11},
To examine the role of BMP signaling during limb pattern formation, we isolated chicken cDNAs encoding type I (BRK-1 and BRK-2) and type II (BRK-3) receptors for bone morphogenetic proteins. BRK-2 and BRK-3, which constitute dual-affinity signaling receptor complexes for BMPs, are co-expressed in condensing precartilaginous cells, while BRK-1 is weakly expressed in the limb mesenchyme. BRK-3 is also expressed in the apical ectodermal ridge and interdigital limb mesenchyme. BRK-2 is intensely… CONTINUE READING

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