BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors

Abstract

The pseudostratified epithelium of the lung contains ciliated and secretory luminal cells and basal stem/progenitor cells. To identify signals controlling basal cell behavior we screened factors that alter their self-renewal and differentiation in a clonal organoid (tracheosphere) assay. This revealed that inhibitors of the canonical BMP signaling pathway… (More)
DOI: 10.1242/dev.126656

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