BMP depletion occurs during prolonged acid demineralization of bone: characterization and implications for graft preparation

@article{Pietrzak2009BMPDO,
  title={BMP depletion occurs during prolonged acid demineralization of bone: characterization and implications for graft preparation},
  author={William S. Pietrzak and S. Nazim Ali and Deepika Chitturi and Mahima Jacob and Jennifer Woodell-May},
  journal={Cell and Tissue Banking},
  year={2009},
  volume={12},
  pages={81-88}
}
Demineralization of allograft bone increases the bioavailability of matrix-associated bone morphogenetic proteins (BMPs), rendering these grafts osteoinductive. While osteoinductivity is related to BMP content, little is known about how the demineralization protocol, in particular, extended demineralization times, affects graft BMP levels. We characterized the BMP-7 content of <710 μm bovine bone powder demineralized under various conditions. Using 1 g of bone per 50 ml of 0.125 N, 0.25 N, or 0… CONTINUE READING

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