BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

@inproceedings{Row2018BMPAF,
  title={BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity},
  author={R. W. Harold Row and Amy Pegg and Brian A Kinney and Gist H. Farr and Lisa Maves and Sally Lowell and Valerie Wilson and Benjamin L Martin},
  booktitle={eLife},
  year={2018}
}
The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these pathways are integrated to induce specific mediolateral cell fates is not well understood. We used mesoderm derived from post-gastrulation neuromesodermal progenitors (NMPs), which undergo a binary mediolateral patterning decision, as a simplified model to understand how FGF acts together with BMP to impart mediolateral fate. Using zebrafish and mouse NMPs, we identify an… CONTINUE READING
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