BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors

@inproceedings{Morikawa2016BMPSE,
  title={BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kr{\"u}ppel-like Factors},
  author={Masato Morikawa and Daizo Koinuma and Anna Mizutani and Natsumi Kawasaki and Katarina Holmborn and Anders Sundqvist and Shuichi Tsutsumi and Tetsuro Watabe and Hiroyuki Aburatani and Carl-Henrik Heldin and Kohei Miyazono},
  booktitle={Stem cell reports},
  year={2016}
}
Bone morphogenetic protein (BMP) signaling exerts paradoxical roles in pluripotent stem cells (PSCs); it sustains self-renewal of mouse embryonic stem cells (ESCs), while it induces differentiation in other PSCs, including human ESCs. Here, we revisit the roles of BMP-4 using mouse ESCs (mESCs) in naive and primed states. SMAD1 and SMAD5, which transduce BMP signals, recognize enhancer regions together with KLF4 and KLF5 in naive mESCs. KLF4 physically interacts with SMAD1 and suppresses its… CONTINUE READING
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