BMP Signaling Mediated by BMPR1A in Osteoclasts Negatively Regulates Osteoblast Mineralization Through Suppression of Cx43.

@article{Shi2017BMPSM,
  title={BMP Signaling Mediated by BMPR1A in Osteoclasts Negatively Regulates Osteoblast Mineralization Through Suppression of Cx43.},
  author={Ce Shi and Honghao Zhang and Ke'ale W. Louie and Yuji Mishina and Hongchen Sun},
  journal={Journal of cellular biochemistry},
  year={2017},
  volume={118 3},
  pages={
          605-614
        }
}
Osteoblasts and osteoclasts are well orchestrated through different mechanisms of communication during bone remodeling. Previously, we found that osteoclast-specific disruption of one of the BMP receptors, Bmpr1a, results in increased osteoblastic bone formation in mice. We hypothesized that BMPR1A signaling in osteoclasts regulates production of either membrane bound proteins or secreted molecules that regulated osteoblast differentiation. In our current study, we co-cultured wild-type… CONTINUE READING
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