BMP Signaling Is Required Locally to Pattern the Dorsal Telencephalic Midline

@article{Hbert2002BMPSI,
  title={BMP Signaling Is Required Locally to Pattern the Dorsal Telencephalic Midline},
  author={Jean M H{\'e}bert and Yuji Mishina and Susan K. McConnell},
  journal={Neuron},
  year={2002},
  volume={35},
  pages={1029-1041}
}
BMPs have been proposed to pattern the medial-lateral axis of the telencephalon in a concentration-dependent manner, thus helping to subdivide the embryonic telencephalon into distinct forebrain regions. Using a CRE/loxP genetic approach, we tested this hypothesis by disrupting the Bmpr1a gene in the telencephalon. In mutants, BMP signaling was compromised throughout the dorsal telencephalon, but only the most dorsalmedial derivative, the choroid plexus, failed to be specified or differentiate… CONTINUE READING
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