BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth.

@article{Li2015BMPSHHSN,
  title={BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth.},
  author={Jingyuan Li and Jifan Feng and Yang Liu and Tuong Vinh Ho and Weston C Grimes and Hoang Anh Ho and Shery S Park and Songlin Wang and Yang Chai},
  journal={Developmental cell},
  year={2015},
  volume={33 2},
  pages={125-35}
}
During embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal organs, such as teeth, hair follicles, mammary glands, and salivary glands. Interestingly, these ectodermal organs differ in their tissue homeostasis, which leads to differential abilities for continuous growth postnatally. Mouse molars lose the ability to grow continuously, whereas incisors retain this ability. In this study, we found that a BMP-Smad4-SHH-Gli1 signaling network may provide a niche… CONTINUE READING
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