BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production

@inproceedings{Park2012BMP9IE,
  title={BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production},
  author={John E. S. Park and Dongmin Shao and Paul D Upton and Patricia Desouza and Ian M. Adcock and Rachel J. Davies and Nicholas W Morrell and Mark J. D. Griffiths and Stephen John Wort},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Bone morphogenetic proteins (BMPs) and their receptors, such as bone morphogenetic protein receptor (BMPR) II, have been implicated in a wide variety of disorders including pulmonary arterial hypertension (PAH). Similarly, endothelin-1 (ET-1), a mitogen and vasoconstrictor, is upregulated in PAH and endothelin receptor antagonists are used in its… CONTINUE READING