BMP-7 represses albumin-induced chemokine synthesis in kidney tubular epithelial cells through destabilization of NF-κB-inducing kinase.

@article{Lim2014BMP7RA,
  title={BMP-7 represses albumin-induced chemokine synthesis in kidney tubular epithelial cells through destabilization of NF-κB-inducing kinase.},
  author={Ai Ing Lim and Loretta Y. Y. Chan and Sydney C. W. Tang and Wai Han Yiu and Ruixi Li and Kar Neng Lai and Joseph C K Leung},
  journal={Immunology and cell biology},
  year={2014},
  volume={92 5},
  pages={
          427-35
        }
}
Protein overload activates proximal tubule epithelial cells (PTECs) to release chemokines. Bone morphogenetic protein-7 (BMP-7) reduces infiltrating cells and tissue damage in acute and chronic renal injuries. The present study examines the inhibitory effect and related molecular mechanism of BMP-7 on chemokine and adhesion molecule synthesis by PTECs activated with human serum albumin (HSA). The expression profiles of chemokines and adhesion molecules in cultured human PTECs were screened by… CONTINUE READING
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