BMP-7-loaded PGLA microspheres as a new delivery system for the cultivation of human chondrocytes in a collagen type I gel: the common nude mouse model.

@article{Gavnis2010BMP7loadedPM,
  title={BMP-7-loaded PGLA microspheres as a new delivery system for the cultivation of human chondrocytes in a collagen type I gel: the common nude mouse model.},
  author={Karsten Gav{\'e}nis and Ulrich Schneider and Juergen Groll and Bernhard Schmidt-Rohlfing},
  journal={The International journal of artificial organs},
  year={2010},
  volume={33 1},
  pages={45-53}
}
PURPOSE Bone morphogenic protein 7 (BMP-7) released from polylactide (PLGA) microspheres has proven to be a potent system in cartilage tissue engineering in vitro. However, in vivo data are still lacking. The aim of this study was to investigate this BMP-7 release system utilizing the nude mouse as a small animal model. METHODS Human osteoarthritic… CONTINUE READING