BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

@article{Luo1995BMP7IA,
  title={BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.},
  author={Guangxiang Luo and Clementine Hofmann and Antonius L.J.J. Bronckers and Melanie M. Sohocki and Allan Bradley and Gerard Karsenty},
  journal={Genes & development},
  year={1995},
  volume={9 22},
  pages={2808-20}
}
Bone morphogenetic proteins (BMPs) are multifunctional growth factors originally identified by their ability to induce ectopic bone formation. To investigate the function of one of the BMPs, BMP-7, we have generated BMP-7-deficient mice using embryonic stem cell technology. BMP-7-deficient mice die shortly after birth because of poor kidney development. Histological analysis of mutant embryos at several stages of development revealed that metanephric mesenchymal cells fail to differentiate… CONTINUE READING
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