BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure.

@article{Davies2003BMP7IA,
  title={BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure.},
  author={Matthew Rhys Davies and Richard J. Lund and Keith A. Hruska},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 6},
  pages={1559-67}
}
Chronic renal failure is complicated by high cardiovascular mortality. One key contributor to this mortality is vascular calcification, for which no therapy currently exists. Bone morphogenetic protein 7 is an essential renal morphogen that maintains renal tubular differentiation in the adult and is downregulated in renal failure. Several studies have demonstrated its efficacy in treating various renal diseases in rodents, and it was hypothesized that it would also be an effective treatment of… CONTINUE READING

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Arterial stiffening and vascular calcifications in end-stage renal disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2000
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