BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β3 expression

@inproceedings{Naber2011BMP7IT,
  title={BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β3 expression},
  author={Hildegonda P. H. Naber and Eliza Wiercinska and Evangelia Pardali and Theo van Laar and Ella Nirmala and Anders Sundqvist and Hans van Dam and Geertje van der Horst and Gabri van der Pluijm and Bertrand Heckmann and Erik H. J. Danen and Peter Ten Dijke},
  booktitle={Cellular Oncology},
  year={2011}
}
The transforming growth factor (TGF)-β superfamily comprises cytokines such as TGF-β and Bone Morphogenetic Proteins (BMPs), which have a critical role in a multitude of biological processes. In breast cancer, high levels of TGF-β are associated with poor outcome, whereas inhibition of TGF-β-signaling reduces metastasis. In contrast, BMP-7 inhibits bone… CONTINUE READING