BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure.

@article{Loureiro2010BMP7BM,
  title={BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure.},
  author={J Rodrigues Loureiro and Margot N. Schilte and Abelardo I Aguilera and Patricia Albar-Vizca{\'i}no and Marta Ram{\'i}rez-Huesca and Mar{\'i}a Luisa P{\'e}rez-Lozano and Guadalupe Tirma G{\'o}nzalez-Mateo and Luiz Stark Aroeira and Rafael Selgas and Lorea Mendoza and Alberto Ortiz and Marta Ruiz-Ortega and Jacob van den Born and Robert J H Beelen and Manuel L{\'o}pez-Cabrera},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2010},
  volume={25 4},
  pages={1098-108}
}
BACKGROUND During peritoneal dialysis (PD), mesothelial cells (MC) undergo an epithelial-to-mesenchymal transition (EMT), and this process is associated with peritoneal membrane (PM) damage. Bone morphogenic protein-7 (BMP-7) antagonizes transforming growth factor (TGF)-beta1, modulates EMT and protects against fibrosis. Herein, we analysed the modulating role of BMP-7 on EMT of MC in vitro and its protective effects in a rat PD model. METHODS Epitheliod or non-epitheliod MC were analysed for… CONTINUE READING