BMP-7 and Bone Regeneration: Evaluation of Dose-Response in a Rodent Segmental Defect Model.


OBJECTIVES To develop and validate a translatable and reproducible rodent critical-sized defect (CSD) model and to determine the optimal dose of recombinant human bone morphogenetic protein (BMP)-7 required to consistently heal the CSD in the new model. METHODS Rats with 6-mm CSDs stabilized with a commercial radiolucent plate and screws with angular… (More)
DOI: 10.1097/BOT.0000000000000307

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