BMP-6 is an autocrine stimulator of chondrocyte differentiation.

  title={BMP-6 is an autocrine stimulator of chondrocyte differentiation.},
  author={C D Grimsrud and Patrick R. Romano and Mary D'Souza and J. Edward Puzas and Paul R Reynolds and Randy N. Rosier and Regis J O'keefe},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={14 4},
While parathyroid hormone-related protein (PTHrP) has been characterized as an important negative regulator of chondrocyte maturation in the growth plate, the autocrine or paracrine factors that stimulate chondrocyte maturation are not well characterized. Cephalic sternal chondrocytes were isolated from 13-day embryos, and the role of bone morphogenetic protein-6 (BMP-6) as a positive regulator of chondrocyte maturation was examined in monolayer cultures. Progressive maturation, which was… CONTINUE READING