BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3.

@article{Kersten2006BMP6IH,
  title={BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3.},
  author={Christian Kersten and Guri Dosen and June H Myklebust and Einar Andreas Sivertsen and Marit Elise Hystad and Erlend Smeland and Edith Rian},
  journal={Experimental hematology},
  year={2006},
  volume={34 1},
  pages={
          72-81
        }
}
OBJECTIVE In mammals, factors produced by bone marrow (BM) stromal cells are instrumental in orchestrating the developmental process of B lymphocytes. Bone morphogenetic proteins (BMPs) are multifunctional cytokines previously found to regulate hematopoietic stem cells. In the present study, we have explored the role of BMP-6 in human B progenitor cells. MATERIALS AND METHODS In vitro B lymphopoiesis of CD10(+) B progenitor cells from human BM was evaluated in the presence or absence of BMP-6… CONTINUE READING
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