BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures.

@article{Mailhot2008BMP5EI,
  title={BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures.},
  author={Genevi{\`e}ve Mailhot and Meiheng Yang and April Mason-Savas and Carole A Mackay and Irwin Leav and Paul R. Odgren},
  journal={Journal of cellular physiology},
  year={2008},
  volume={214 1},
  pages={56-64}
}
Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through phenotypes of short-ear (se) mice, which have BMP-5 mutations, a role for BMP-5 in some specific aspects of skeletogenesis and cartilage growth is known. This report examines BMP-5 expression in the growth plate and in differentiating cultures of primary chondrocytes, and the effects of addition of BMP-5 or its inhibition by anti-BMP-5 antibody in chondrocyte cultures. By laser capture… CONTINUE READING

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