BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells.

@article{Li2008BMP2PP,
  title={BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells.},
  author={Xianwu Li and H L Yang and Cecilia M. Giachelli},
  journal={Atherosclerosis},
  year={2008},
  volume={199 2},
  pages={271-7}
}
Vascular calcification is associated with increased risk of cardiovascular events that are the most common cause of death in patients with end-stage renal disease. Clinical and experimental studies indicate that hyperphosphatemia is a risk factor for vascular calcification and cardiovascular mortality in these patients. Our previous studies demonstrated that phosphate transport through the type III sodium-dependent phosphate cotransporter, Pit-1, was necessary for phosphate-induced… CONTINUE READING