BMP-2 peptide-functionalized nanopatterned substrates for enhanced osteogenic differentiation of human mesenchymal stem cells.

@article{Kim2013BMP2PN,
  title={BMP-2 peptide-functionalized nanopatterned substrates for enhanced osteogenic differentiation of human mesenchymal stem cells.},
  author={Mun-Jung Kim and Bora Lee and Kisuk Yang and Junyong Park and Seokwoo Jeon and Soong Ho Um and Dong-ik Kim and Sung Gap Im and Seung-Woo Cho},
  journal={Biomaterials},
  year={2013},
  volume={34 30},
  pages={7236-46}
}
A variety of biophysical and biochemical factors control stem cell differentiation. In this study, we developed a nanopatterned substrate platform to surface immobilize osteoinductive bone morphogenetic protein-2 (BMP-2) peptides. Specifically, polyurethane acrylate (PUA) substrates with nanometer-scale groove- and dot-shaped topography were fabricated. The nanopatterned PUA surface was uniformly coated with poly(glycidyl methacrylate) (pGMA) by initiated chemical vapor deposition (iCVD… CONTINUE READING