BMP-2 incorporated in a tricalcium phosphate bone substitute enhances bone remodeling in sheep.

@article{Maus2008BMP2II,
  title={BMP-2 incorporated in a tricalcium phosphate bone substitute enhances bone remodeling in sheep.},
  author={Uwe M. Maus and Stefan Andereya and Sascha Gravius and J{\"o}rg A. K. Ohnsorge and Christopher Niedhart and Christian Helge Siebert},
  journal={Journal of biomaterials applications},
  year={2008},
  volume={22 6},
  pages={559-76}
}
Bone morphogenetic protein-2 (BMP-2) is a well-known osteoinductive protein, which requires a carrier for local application. As an alternative to the previously described carriers, an in situ hardening, resorbable, and osteoconductive beta-tricalcium phosphate cement (TCP) is tested. Trepanation defects in the bovine distal femoral epiphysis are filled with a composite consisting of TCP and 200 microg rhBMP-2 per cm3 TCP, autologous bone graft, pure TCP, or left empty. A radiological follow-up… CONTINUE READING