BMP-2 for intramuscular bone induction: effect in squirrel monkeys is dependent on implantation site.

@article{Aspenberg1996BMP2FI,
  title={BMP-2 for intramuscular bone induction: effect in squirrel monkeys is dependent on implantation site.},
  author={Per Aspenberg and Tom Turek},
  journal={Acta orthopaedica Scandinavica},
  year={1996},
  volume={67 1},
  pages={
          3-6
        }
}
Demineralized bone matrix (DBM) reproducibly induces extraskeletal bone formation in rodents, but its effects in dogs and primates are negative or uncertain. In previous studies on the squirrel monkey, DBM did not induce bone, although the same implants were effective in rats. DBM implants augmented with recombinant human bone morphogenetic protein-2 (rhBMP-2) induced intramuscular bone formation in squirrel monkeys. However, the amount of induced bone was often minimal and sometimes absent… CONTINUE READING
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