BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells

@article{Song2014BMP2AT,
  title={BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells},
  author={Rui Song and David Fullerton and Lihua Ao and Daniel J Zheng and Ke-Seng Zhao and Xianzhong Meng},
  journal={Journal of Molecular Medicine},
  year={2014},
  volume={93},
  pages={403-412}
}
Biglycan accumulates in aortic valves affected by calcific aortic valve disease (CAVD), and soluble biglycan upregulates BMP-2 expression in human aortic valve interstitial cells (AVICs) via Toll-like receptor (TLR) 2 and induces AVIC pro-osteogenic reprogramming, characterized by elevated pro-osteogenic activities. We sought to identify the factors responsible for biglycan-induced pro-osteogenic reprogramming in human AVICs. Treatment of AVICs with recombinant biglycan induced the secretion of… CONTINUE READING

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