BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation.

  title={BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation.},
  author={Todd A Townsend and Jamille Y. Robinson and Christopher R. Deig and Cynthia R Hill and Andrew M Misfeldt and Gerard C. Blobe and Joey V. Barnett},
  journal={Cells, tissues, organs},
  volume={194 1},
Valvular heart disease is a major cause of mortality and morbidity. Revealing the cellular processes and molecules that regulate valve formation and remodeling is required to develop effective therapies. A key step in valve formation during heart development is the epithelial-mesenchymal transformation (EMT) of a subpopulation of endocardial cells in the atrioventricular cushion (AVC). The type III transforming growth factor-β receptor (TGFβR3) regulates AVC endocardial cell EMT in vitro and… CONTINUE READING


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