BMP-2 Is Involved in Scleral Remodeling in Myopia Development

  title={BMP-2 Is Involved in Scleral Remodeling in Myopia Development},
  author={Honghui Li and Dongmei Cui and Feng Zhao and L. Gao-Y. Zhou-C. Li-L. Huo and Jianmin Hu and Junwen Zeng},
  booktitle={PloS one},
The development of myopia is associated with scleral remodeling, but it is unclear which factors regulate this process. This study investigated bone morphogenetic protein-2 (BMP-2) expression in the sclera of guinea pigs with lens-induced myopia (LIM) and after recovery from myopia and evaluated the effect of BMP-2 on extracellular matrix (ECM) synthesis in human scleral fibroblasts (HSFs) cultured in vitro. Lens-induced myopia was brought about in two groups of guinea pigs (the lens-induced… CONTINUE READING


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