BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis.

@article{Gupta2000BMP2ALK3AH,
  title={BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis.},
  author={Indra Rani Gupta and Marina Mac{\'i}as-Silva and Sung-Eun Kim and Xueyuan Zhou and Tino D. Piscione and Catharine Whiteside and Jeffrey L. Wrana and Norman D Rosenblum},
  journal={Journal of cell science},
  year={2000},
  volume={113 Pt 2},
  pages={269-78}
}
Bone morphogenetic protein (BMP)-2 and hepatocyte growth factor (HGF) exert antagonistic effects on renal collecting duct formation during embryogenesis. A current model proposes HGF inhibits BMP-2 signaling at the level of Smad1 in a common target cell. Here, we show that BMP-2 and HGF control collecting duct formation via parallel pathways. We examined the interactions between BMP-2 and HGF in the mIMCD-3 model of collecting duct morphogenesis. During tubule formation, HGF rescued the… CONTINUE READING
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