BML‐190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates

@article{New2003BML190AA,
  title={BML‐190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates},
  author={David C. New and Yung H. Wong},
  journal={FEBS Letters},
  year={2003},
  volume={536}
}
  • D. New, Y. Wong
  • Published 11 February 2003
  • Biology, Chemistry
  • FEBS Letters
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febs.onlinelibrary.wiley.com
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  • 2005
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More information is beginning to emerge about the pharmacological actions of the non-psychoactive plant cannabinoid, cannabidiol, as well as acting on CB1 and CB2 receptors, and there is convincing evidence that anandamide can activate transient receptor potential vanilloid type 1 (TRPV1) receptors.
Tetrahydrocannabinol‐induced neurotoxicity depends on CB1 receptor‐mediated c‐Jun N‐terminal kinase activation in cultured cortical neurons
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It is reported that THC induces the activation of JNK via the CB1 receptor and its associated G‐protein, Gi/o.n‐terminal kinase, central to the THC‐induced activation of the apoptotic pathway in cortical neurons.
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The inhibitory action of exo- and endocannabinoids on [3H]GABA release are mediated by both CB1 and CB2 receptors in the mouse hippocampus
Functional CB2 type cannabinoid receptors at CNS synapses
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A role for cannabinoid receptors in proximal tubule cells is identified which may provide novel therapeutic targets for the treatment of diabetes and obesity.
Detecting constitutive activity and protean agonism at cannabinoid-2 receptor.
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The protocol used provides an in vitro model system expressing CB1 cannabinoid receptors at the level of mRNA, protein, and AM251‐sensitive agonist‐induced inhibition of intracellular cyclic AMP accumulation, which may be useful to investigate the developmental regulation, expression and function of neuronal cannabinoid receptors.
Characterization of human cannabinoid CB2 receptor coupled to chimeric Galpha(qi5) and Galpha(qo5) proteins.
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