BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer

@inproceedings{Zhang2009BMI1AM,
  title={BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer},
  author={Xiao-Wei Zhang and Ya-Ping Sheng and Qian Li and Wei Qin and Y Q Lu and Yufan Cheng and Bing-Ya Liu and Feng-chun Zhang and Jin Li and Goberdhan P Dimri and Weijian Guo},
  booktitle={Molecular Cancer},
  year={2009}
}
The BMI1 oncogene is overexpressed in several human malignancies including gastric cancer. In addition to BMI1, mammalian cells also express Mel-18, which is closely related to BMI1. We have reported that Mel-18 functions as a potential tumor suppressor by repressing the expression of BMI1 and consequent downregulation of activated AKT in breast cancer cells. However, the mechanisms of BMI1 overexpression and the role of Mel-18 in other cancers are still not clear. The purpose of this study is… CONTINUE READING