BMI-1 is highly expressed in M0-subtype acute myeloid leukemia.

  title={BMI-1 is highly expressed in M0-subtype acute myeloid leukemia.},
  author={Masashi Sawa and Kazuhito Yamamoto and Toshiya Yokozawa and Hitoshi Kiyoi and Asahi Hishida and Tomohiro Kajiguchi and Masao Seto and Akio Kohno and Kunio Kitamura and Yoshie Itoh and Norio Asou and Nobuyuki Hamajima and Nobuhiko Emi and Tomoki Naoe},
  journal={International journal of hematology},
  volume={82 1},
Recent studies have suggested that one of the polycomb group genes, BMI-1, has an important role in the maintenance of normal and leukemic stem cells by repressing the INK4a/ARF locus. Here, we quantitatively examined BMI-1 expression level in samples from patients with acute myeloid leukemia (AML) and other hematologic malignancies. Moderate to high BMI-1 expression was detected in AML patients, and the BMI-1 expression levels in AML samples were significantly higher than in normal bone marrow… CONTINUE READING


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