BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.

@article{Be2001BMI1GA,
  title={BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.},
  author={S{\'i}lvia Be{\`a} and Frederic Tort and Magda Pinyol and Xavier Puig and Luis Hern{\'a}ndez and Silvia Hern{\'a}ndez and P L Fern{\'a}ndez and Maarten van Lohuizen and Dolors Colomer and El{\'i}as Campo},
  journal={Cancer research},
  year={2001},
  volume={61 6},
  pages={2409-12}
}
The BMI-1 gene is a putative oncogene belonging to the Polycomb group family that cooperates with c-myc in the generation of mouse lymphomas and seems to participate in cell cycle regulation and senescence by acting as a transcriptional repressor of the INK4a/ARF locus. The BMI-1 gene has been located on chromosome 10p13, a region involved in chromosomal translocations in infant leukemias, and amplified in occasional non-Hodgkin's lymphomas (NHLs) and solid tumors. To determine the possible… CONTINUE READING