BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore.

@article{Risso2002BMAP28AA,
  title={BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore.},
  author={Angela Risso and Enrico Braidot and Maria Concetta Sordano and A Vianello and Francesco Macr{\`i} and Barbara Skerlavaj and Margherita Zanetti and Renato Gennaro and Paolo Bernardi},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 6},
  pages={1926-35}
}
BMAP-28, a bovine antimicrobial peptide of the cathelicidin family, induces membrane permeabilization and death in human tumor cell lines and in activated, but not resting, human lymphocytes. In addition, we found that BMAP-28 causes depolarization of the inner mitochondrial membrane in single cells and in isolated mitochondria. The effect of the peptide… CONTINUE READING