BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis

@article{Rudic2004BMAL1AC,
  title={BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis},
  author={Radu Daniel Rudic and P Mcnamara and A S Curtis and Raymond C. Boston and Satchidananda Panda and John B. Hogenesch and Garret A. FitzGerald},
  journal={PLoS Biology},
  year={2004},
  volume={2},
  pages={540 - 550}
}
Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis. Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Gluconeogenesis is abolished by deletion of Bmal1 and is depressed in Clock mutants, but the… CONTINUE READING
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