BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.

  title={BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.},
  author={Paul A. Moore and Ornella Belvedere and Anne V Orr and K Pieri and David W Lafleur and Ping Feng and Dan Soppet and M Charters and Reiner Gentz and David Parmelee and Yanchun Li and Olga Galperina and J. Giri and Viktor V. Roschke and Bernardetta Nardelli and Jeffrey Carrell and Svetlana A. Sosnovtseva and W. J. Greenfield and Steve M. Ruben and Henrik S Olsen and James Fikes and David M. Hilbert},
  volume={285 5425},
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice… CONTINUE READING
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