BLTK1 murine Leydig cells: a novel steroidogenic model for evaluating the effects of reproductive and developmental toxicants.

@article{Forgacs2012BLTK1ML,
  title={BLTK1 murine Leydig cells: a novel steroidogenic model for evaluating the effects of reproductive and developmental toxicants.},
  author={Agnes L Forgacs and Qi Ding and Rosemary G Jaremba and Ilpo Tapani Huhtaniemi and Nafis Rahman and T. R. Zacharewski},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={127 2},
  pages={391-402}
}
Leydig cells are the primary site of androgen biosynthesis in males. Several environmental toxicants target steroidogenesis resulting in both developmental and reproductive effects including testicular dysgenesis syndrome. The aim of this study was to evaluate the effect of several structurally diverse endocrine disrupting compounds (EDCs) on steroidogenesis in a novel BLTK1 murine Leydig cell model. We demonstrate that BLTK1 cells possess a fully functional steroidogenic pathway that produces… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 81 references

The foetal Leydig cell-- differentiation, function and regulation.

International journal of andrology • 2006
View 4 Excerpts
Highly Influenced

In Aging and the Decline of Androgen Production (A

H. Chen, A. Midzak, L. Luo, B. R. Zirkin
2007
View 5 Excerpts
Highly Influenced

Chemical regulators have overreached

View 2 Excerpts
Highly Influenced

The effects of triclosan on puberty and thyroid hormones in male Wistar rats.

Toxicological sciences : an official journal of the Society of Toxicology • 2009
View 4 Excerpts
Highly Influenced

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