BLM is an early responder to DNA double-strand breaks.

  title={BLM is an early responder to DNA double-strand breaks.},
  author={Parimal Karmakar and Masayuki Seki and Makoto Kanamori and Kazunari Hashiguchi and Makoto Ohtsuki and Eriko Murata and Eri Inoue and Shusuke Tada and Li Lan and Akira Yasui and Takemi Enomoto},
  journal={Biochemical and biophysical research communications},
  volume={348 1},
Bloom syndrome (BS) is an autosomal recessive disorder characterized by a marked predisposition to cancer and elevated genomic instability. The defective protein in BS, BLM, is a member of the RecQ helicase family and is believed to function in various DNA transactions, including in replication, repair, and recombination. Here, we show that both endogenous… CONTINUE READING