BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.

@article{Grierson2012BLMHF,
  title={BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.},
  author={Patrick M Grierson and Kate Lillard and Gregory K. Behbehani and Kelly A. Combs and Saumitri Bhattacharyya and Samir Acharya and Joanna Groden},
  journal={Human molecular genetics},
  year={2012},
  volume={21 5},
  pages={
          1172-83
        }
}
Bloom's syndrome (BS) is an autosomal recessive disorder that is invariably characterized by severe growth retardation and cancer predisposition. The Bloom's syndrome helicase (BLM), mutations of which lead to BS, localizes to promyelocytic leukemia protein bodies and to the nucleolus of the cell, the site of RNA polymerase I-mediated ribosomal RNA (rRNA) transcription. rRNA transcription is fundamental for ribosome biogenesis and therefore protein synthesis, cellular growth and proliferation… CONTINUE READING
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