BL-7010 Demonstrates Specific Binding to Gliadin and Reduces Gluten-Associated Pathology in a Chronic Mouse Model of Gliadin Sensitivity

Abstract

Celiac disease (CD) is an autoimmune disorder in individuals that carry DQ2 or DQ8 MHC class II haplotypes, triggered by the ingestion of gluten. There is no current treatment other than a gluten-free diet (GFD). We have previously shown that the BL-7010 copolymer poly(hydroxyethyl methacrylate-co-styrene sulfonate) (P(HEMA-co-SS)) binds with higher… (More)
DOI: 10.1371/journal.pone.0109972

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@inproceedings{Mccarville2014BL7010DS, title={BL-7010 Demonstrates Specific Binding to Gliadin and Reduces Gluten-Associated Pathology in a Chronic Mouse Model of Gliadin Sensitivity}, author={Justin L. Mccarville and Yotam Nisemblat and Heather J. Galipeau and Jennifer Jury and Rinat Tabakman and Ad Cohen and Esmira Naftali and Bela Neiman and Efrat Halbfinger and J A Murray and Arivarasu Natarajan Anbazhagan and Pradeep K. Dudeja and Alexander Varvak and Jean-Christophe Leroux and Elena Verd{\'u}}, booktitle={PloS one}, year={2014} }