BK-virus nephropathy in renal transplants-tubular necrosis, MHC-class II expression and rejection in a puzzling game.

@article{Nickeleit2000BKvirusNI,
  title={BK-virus nephropathy in renal transplants-tubular necrosis, MHC-class II expression and rejection in a puzzling game.},
  author={Volker Nickeleit and Hans Hellmuth Hirsch and Matthias Zeiler and Fred G. Gudat and Olivier D Prince and Gilbert T Thiel and Michael J{\"o}rg Mihatsch},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2000},
  volume={15 3},
  pages={324-32}
}
We review BK-virus nephropathy (BKN) as a new complication that increasingly affects renal allografts and causes dysfunction. Since starting in 1996, we have seen 11 cases. Currently, the prevalence of BKN is 3% in our graft biopsies. The diagnosis can only be made histologically. The virus affects tubular epithelial cells that show characteristic intranuclear inclusion bodies. The major reason for impaired graft function and a possible way for viral particles to gain access to the blood via… CONTINUE READING
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