BK virus-associated urinary bladder carcinoma in transplant recipients: report of 2 cases, review of the literature, and proposed pathogenetic model.

@article{Alexiev2013BKVU,
  title={BK virus-associated urinary bladder carcinoma in transplant recipients: report of 2 cases, review of the literature, and proposed pathogenetic model.},
  author={Borislav A. Alexiev and Parmjeet A Randhawa and Eduardo Vazquez Martul and Gang Zeng and Chunqing Luo and Emilio Ramos and Cinthia B Drachenberg and John C. Papadimitriou},
  journal={Human pathology},
  year={2013},
  volume={44 5},
  pages={908-17}
}
Despite strong experimental evidence, BK polyomavirus involvement in human cancers has been controversial. We report 2 cases of kidney ± pancreas transplant recipients with evidence of BK polyomavirus reactivation, who developed aggressive urinary bladder urothelial carcinomas with adenocarcinomatous and/or micropapillary differentiation. Diffuse strong nuclear positivity for viral T antigen, p53, Ki-67, and p16 was observed in both malignancies. The BK polyomavirus role in promoting urothelial… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2018

BK Polyomavirus Genomic Integration and Large T Antigen Expression: Evolving Paradigms in Human Oncogenesis.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2017

[Urologic malignancies in renal transplant candidates and recipients].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie • 2016

References

Publications referenced by this paper.
Showing 1-10 of 22 references

BK polyomavirus and transformation. In: Robertson ES, editor. Cancer Associated Viruses, Current Cancer Research

T Dalianis, HH Hirsch
New York, NY: Springer Science • 2012
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…